The difference with 1-Up Events was that the entrance fee was £12.50 (probably more than $20 for you Americans), which people had to pay on top of their travel money. That's a lot of money to play Pokémon, and the official tournaments wouldn't charge entrance fees (although I'm sure a lot of VGC players would accept paying a small fee if it meant that TPCi could give out more paid invites, but that's for another discussion). I myself spent over £200 going to the official VGC, and the 1-Up tournaments, I don't think many players would be willing to stretch that far.
Regardless, I do understand that the UK (and most European countries) are generally too small to warrant multiple regional tournaments. However, I'm not talking eight or more like the USA, I'm thinking maybe four at the most. It'd just be better for most players if we could have a swiss + best-of-three National tournament in the UK. We obviously can't do this with 512+ players at once, but four or so regional tournaments with invites, and then a LCQ would suffice.
Hoyle is right about the TCG tournaments in the UK. The invite system doesn't have to work the same as TCG, but playing a VGC tournament at each TCG event is seemingly what could happen, so it's feasible to allow Nationals invites for the top placers, especially since the LCQ would be there anyway. If you want to wait until that, you're welcome to. It's exactly the same as the US but on a smaller scale.
I agree with Firestorm and Hoyle for the most part. However, while the regional tournaments may have a low-ish turnout, they'd still be fun and due to having a LCQ at wherever the main National tournament is, the turnout to that would still be relatively large.
I also wouldn't be expecting major prizes at regional tournaments if that was on anyone's mind. TCG tournaments I've been to just give out booster packs and medals for the most part. I'd be completely happy with small regional tournaments where all you get is your Nationals invite and a medal for 1st & 2nd. That seems completely fair and not overly costly.
I don't think two Nationals in each European country would work, or be fair on Japan or America. It'd be too hard to space them apart, and running them both on the same day would require more staff and only hinder the turnout of each one (not to mention defeating the purpose of giving people the chance at actually losing a game and still progressing, as they'd have to go to one or the other, not both).